Grade Level

High School




Rebecca Clements, David Mangus

Lesson Summary

This lesson provides students with an opportunity to engage with research demonstrating evolution in real-time. Students will confront many misconceptions about how evolution works, and will come to understand how evolution affects human health. Upon completion of this lesson, students will be able to:

  • explain that a population is a group of individuals with different traits and characteristics;
  • describe that diversity in a population is the result of accumulated changes in the DNA sequence;
  • explain that natural selection identifies individuals with traits best suited for a particular environment; and
  • argue from evidence why overuse of antibiotics is leading to a public health crisis.

Additional Documents:

Optional Day 2 Classroom activity – Modeling of MEGA-plate with “Bacterial Invasion!” board game activity.

Black-and-white versions of the color images used in the lesson.


Science and Engineering Practices:

SP2, SP6, SP7

MA Science and Technology/Engineering (2016):

HS-LS3-4(MA), HS-LS4-2, HS-LS4-4

NGSS (2013):

HS-LS4-2, HS-LS4-4

Common Core Math/Language Arts Standards:



antibiotic resistance, ingestion, microbiome, mutation

Educator SoundBites

"The depth of the questions encouraged students to critically think and collaborate with their peers."
Danika Korpacz, Central Falls HS, Central Falls, RI

Lesson Documents


Download PDF View Google Doc


Download PDF View Google Doc


Download PDF View Google Doc

Full Lesson

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